Endocrine Abstracts

Objective: To investigate a possible association of DRB1, DQA1 and DQB1 alleles with the chronic autoimmune thyroiditis (AT) development in patients with diabetes mellitus type 1 (DM1) manifested between 18 to 40 years of age. Patients and methods: In 118 patients with DM1 (age at DM1 diagnosis 28.0 (6.9) years, duration of DM1 14.0 (6.3) years) HLA-DRB1, -DQA1 and -DQB1 alleles were analysed by sequence specific oligonucleotide probes and sequence specific primers. AT was pre...